ATP2C1 (4G12) Antibody

Cat no: 252961

Supplier: ABBIOTEC

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Description
Additional Information

ATP2C1 (Calcium-transporting ATPase type 2C member 1) belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi comple, Xenopus/Amphibian, and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calciu ATPase (PCMA). ATP2C is a transmembrane protein that e, Xenopus/Amphibian,ists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.

Catalogue number:	252961
Reactivities:	Human, Mouse
Applications:	Immunohistochemistry
Size:	0.1 ml
Accession:	P98194
Antigen:	Purified recombinant fragment of ATP2C1 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	4G12
Additional info:	Calcium-transporting ATPase type 2C member 1; ATPase 2C1; ATP-dependent Ca(2+) pump PMR1; HUSSY-28; KIAA1347; PMR1L; ATP2C1