Aureothricin (Propionylpyrrothione, Farcinin)

Cat no: A4174-50

Supplier: United States Biological

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Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Aureothricin is a more hydrophobic analogue of thiolutin but has received only limited attention. Members of this class, notably, thiolutin, have been shown to potent inhibitors of bacterial and yeast RNA polymerases and inhibitors of mannan and glucan formation in fungi. Studies have shown that thiolutin inhibits tumor cell-induced angiogenesis in vivo. DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water

Catalogue number:	A4174-50
Size:	500ug
Form:	Yellow orange solid
Purity:	> 98% by HPLC
Alternative names:	Propionylpyrrothione, Farcinin
References:	1. Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W. D. and Solomons I.A. Antibiotics Annual 1953, 622. 2. Anticancer property of dithiolopyrrolones. Webster J.M. et. al. 2000, US Patent 6,020,360. 3. Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245. 4. Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Minamiguchi K. Int. J. Cancer 2001, 93, 307. 5. Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. L133 Antimicrob Agents Chemother. 1973, 3, 729.

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Aureothricin (Propionylpyrrothione, Farcinin)

Cat no: A4174-50

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