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Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)

Aven (Apoptosis Caspase Activation Inhibitor, Cell Death Regulator Aven, PDCD12)

Cat no: A4445-11L

Supplier: United States Biological
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PDCD12 (Programmed cell death 12), also referred to as AVEN, represents a new class of cell death regulator. PDCD12 is a conserved intracellular membrane protein that blocks apoptosis impeded by Apaf-1 mediated caspase activation. Bcl-2 and BAD also interact with PDCD12 to prevent apoptosis. It is expressed in a wide variety of normal tissues including heart, skeletal muscle, kidney, liver, testis, and diseases such as cancer Applications: Suitable for use in ELISA and Western Blot Other applications not tested. Recommended Dilution: Western Blot: 1:1000-3000 Optimal dilutions to be determined by the researcher. Hybridoma: Hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PDCD12 protein. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A4445-11L
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Figueroa B Jr, et al: (2004) Biotechnol Bioeng. 85(6), 589-600 2. Cheng EH, et al: (2000) Mol Cell. 6(1), 31-40
Additional info: Recognizes human PDCD12 (Programmed cell death 12, AVEN).

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