Home  >  Products  >  b-Amyloid Protein 42, Recombinant, Human (ABPP, APPI, APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, APP, A4, AD1)
b-Amyloid Protein 42, Recombinant, Human (ABPP, APPI, APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, APP, A4, AD1)

b-Amyloid Protein 42, Recombinant, Human (ABPP, APPI, APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, APP, A4, AD1)

Cat no: A2275-86G

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Beta-amyloid (Abeta) peptides result from the proteolytic cleavage of beta-amyloid precursor protein (APP) which is encoded by a gene located on chromosome 21. Abeta is produced by two proteases (beta- and gamma- secretase) and has vary forms (39- and 43-mer peptides). Abeta40 and Abeta42 peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease (AD). Abeta42 plays a critical role in the pathogenesis of AD since its aggregative ability and neurotoxicity are much greater than these of Abeta40. Abeta42 oligomers initially formed as a seed accelerate the aggregation of Abeta40 to form the amyloid plaques that eventually lead to the neurodegeneration (amyloid cascade hypothesis). Abeta40 also serves as an antioxidant molecule by quenching metal ions and inhibiting metal-mediated oxygen radical generation. Source: Recombinant corresponding to aa1-42, with N-GST tag, from human beta-Amyloid 42, expressed in E.coli. Molecular Weight: ~31kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A2275-86G
Size: 500ug
Form: Supplied as a liquid in 20mM HEPES, pH 7.0, 10% glycerol.
Purity: ~95% (SDS-PAGE)
References: 1. Kazuhiro Irie et al. (2005) Journal of bioscience and bioengineering 99(5):437-447. 2. Andreas Kern et al. (2005) Journal of Biological Chemistry published on November 22. 3. John hardy et al. (2002) Science 297(19):353-356. 4. Zou K. et al. (2003) J Neurochem. 87(3):609-619.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave