BCMA is a member of the TNF receptor superfamily. It binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines. It plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184aa type I transmembrane protein, which contains a 54aa extracellular domain, a 23aa transmembrane domain, and a 107aa extracellular domain. Recombinant soluble BCMA is a 50aa polypeptide (5.3kD) comprising the TNFR homologous region of the BCMA protein.
Recombinant protein corresponding to human B Cell Maturation Protein expressed in E. coli
AA Sequence: AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Reconstitute with sterile ddH2O, 0.1% BSA or HSA. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Country of Origin:
USA
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