

Supplier:
United States BiologicalCat no: B0003-01A
BACE2, Asp1 (NT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2, DRAP, Down Region Aspartic Protease, Memapsin)
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SPECIFICATIONS
Catalog Number
B0003-01A
Size
100ug
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat
Form
Supplied as a liquid in PBS with 0.02% sodium azide.
P Type
Pab
Purity
Purified IgG was prepared from whole serum by affinity chromatography.
Isotype
IgG
References
1. Farzan, M. et al. (2000). Bace2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl. Acad. Sci. 15: 9712-7.
Additional Info
Recognizes an epitope within the N-terminal region of BACE2, a homologue of the beta-site APP cleaving enzyme (BACE). BACE2 has been reported to cleave the beta-amyloid precursor protein (APP) at the beta-site, producing amyloid-beta protein (ABeta). Accumulation of ABeta plaques in the cerebral cortex play an important role in the pathogenesis of Alzheimer's disease, particularly in individuals bearing the Flemish mutation. Species crossreactivity Mouse, rat
SUPPLIER INFO
Applications
ELISA, WB
Hosts
Rabbit
Reactivities
Hum, Mouse
Applications
ELISA, IHC, WB
Hosts
Rabbit
Reactivities
Hum, Mouse
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