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Bad (Bcl2 Antagonist of Cell Death, Bcl-2-binding Component 6, Bcl-xL/Bcl-2-associated Death Promoter, Bbc6)

Bad (Bcl2 Antagonist of Cell Death, Bcl-2-binding Component 6, Bcl-xL/Bcl-2-associated Death Promoter, Bbc6)

Cat no: B0003-53A

Supplier: United States Biological
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Members of the Bcl-2 family of proteins are important regulators of programmed cell death (reviewed in 1-3). This family of proteins includes both anti-apoptotic molecules such as Bcl-2 and Bcl-X(L), and pro-apoptotic molecules such as Bax, Bak, Bid, and Bad. The deregulation of the various Bcl-2 family member proteins has been implicated in many pathological conditions. For example, overexpression of anti-apoptotic molecules including Bcl-2, Bcl-X(L), or both has been associated with a number of human cancers, and may play a critical role in cancer progression. Anti-apoptotic Bcl-2 family members appear to function, at least in part, by interacting with and antagonizing pro-apoptotic family members. Bad is also known as BCL2-antagonist of cell death, BCL2-binding protein, BCL2-binding component, and BCL-X:BCL-2 binding protein. Bad regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0003-53A
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Chan SL and Yu VC. 2004. Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities. Clin Exp Pharmacol Physiol. 31:119-128. 2. Kirkin V, Joos S, and Zornig M. 2004. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta. 1644:229-249. 3. Soreson CM. 2004. Bcl-2 family members and disease. Biochim Biophys Acta. 1644:169-177.
Additional info: Recognizes mouse Bad. Species Crossreactivity: rat.

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