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BAF57 (BRG1 Associated Factor 57, Mammalin Chromatin Remodeling Complex, SMARCE1, SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin e1)

BAF57 (BRG1 Associated Factor 57, Mammalin Chromatin Remodeling Complex, SMARCE1, SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin e1)

Cat no: B0003-63P

Supplier: United States Biological
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The SWI/SNF complex in S. cerevisiae and Drosophila is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. The complex contains an ATP-dependent nucleosome disruption activity that can lead to enhanced binding of transcription factors. The BRG1/brm associated factors, or BAF, complex in mammals is functionally related to SWI/SNF and consists of 9 to 12 subunits, some of which are homologous to SWI/SNF. A 57kD BAF subunit, BAF57, is present in higher eukaryotes, but not in yeast. Cellular Localization: Nuclear Positive Control: HeLa or Jurkat whole cell lysate. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000. Western Blot: 1ug/ml. ~ 37kD band in Hela and Human Brain lysates. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B0003-63P
Reactivities: Human, Mouse
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Wang W et al. Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. Proc Natl Acad Sci U S A 95:492-8 (1998).
Additional info: Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (99% identity with immunogen) due to sequence homology.

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