Home  >  Products  >  BAFF Receptor, CT (BAFFR, BAFF-R, B Cell-Activating Factor Receptor, BLyS Receptor 3, BR3, CD268, CD268 Antigen, MGC138235, Tumor Necrosis Factor Receptor Superfamily Member 13C, TNFRSF13C)
BAFF Receptor, CT (BAFFR, BAFF-R, B Cell-Activating Factor Receptor, BLyS Receptor 3, BR3, CD268, CD268 Antigen, MGC138235, Tumor Necrosis Factor Receptor Superfamily Member 13C, TNFRSF13C)

BAFF Receptor, CT (BAFFR, BAFF-R, B Cell-Activating Factor Receptor, BLyS Receptor 3, BR3, CD268, CD268 Antigen, MGC138235, Tumor Necrosis Factor Receptor Superfamily Member 13C, TNFRSF13C)

Cat no: B0003-68W

Supplier: United States Biological
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Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-5ug/ml Immunohistochemistry (paraffin): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human(H), mouse(M), and rat(R) spleen tissue lysates. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0003-68W
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260. 2. Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56. 3. Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. J Biol Chem 1999;274:15978-81. 4. Thompson JS, Bixler SA, Qian F, et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science. 2001;293:2108-11.
Additional info: Recognizes human BAFF-R (CT). Species Crossreactivity: mouse and rat.

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