BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFFR is a 76aa polypeptide (7.7kD) corresponding to the extracellular portion of the full BAFFR protein.
Source:
Recombinant protein corresponding to human BAFF Receptor, expressed in E.coli.
Biological Activity:
Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2-4ug/ml in the presence of 1ug/ml of human soluble BAFF.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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