Bafilomycin A1 is a member of a potent family of macrocyclic lactones with a broad spectrum of biological activity including activity against bacteria, yeast, fungi, nematodes, insects and antitumor cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.
Related to: Bafilomycin B1, Bafilomycin C1, Concanamycin A
Solubility:
Freely soluble in DMSO; may react with methanol or ethanol, so these solvents are not recommended for stock solutions; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Melting Point:
151.5-152C
Elemental Analysis:
Calculated:
C: 67.49%
H: 9.39%
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light.
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