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Bak, NT (BAK1, BCL2 Homologous Antagonist/Killer, CDN1, BCL2L7, Apoptosis Regulator BAK, Bcl-2-like Protein 7, Bcl2-L-7)

Bak, NT (BAK1, BCL2 Homologous Antagonist/Killer, CDN1, BCL2L7, Apoptosis Regulator BAK, Bcl-2-like Protein 7, Bcl2-L-7)

Cat no: B0055-10M

Supplier: United States Biological
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Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl- 2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a member of pro-apoptotic Bcl-2 family, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro- apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0055-10M
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Purity: Purified by Ion Exchange chromatography.
References: 1. Heiser, D. et al. Exp Geron 39, 1125 (2004). 2. Cory, S. et al. Oncogene 22, 8590 (2003). 3. Mikhailov, V. et al. J Biol Chem 278, 5367 (2003). 4. Zong, WX. et al. Genes Dev 15, 1481 (2001). 5. Lindsten, T. et al. Mol Cell 6, 1389 (2000). 6. Lockshin, RA. et al. Cell Death Differ 7, 2 (2000). 7. Kiefer, M. et al. Nature 374, 736 (1995).
Additional info: Recognizes human Bak. Species Crossreactivity: mouse.

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