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Bax, beta, NT (Bcl2-associated X Protein, b, Bax2, zgc:112983)

Bax, beta, NT (Bcl2-associated X Protein, b, Bax2, zgc:112983)

Cat no: B0175-18M

Supplier: United States Biological
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Members of the Bcl-2 gene family are critical mediators of the delicate balance between survival and apoptosis in eucaryotic cells.The Bcl-2 family consists of three classes of proteins: prosurvival (including Bcl-2, Bcl-xL, Mcl-1, A1, Boo/DIVA, Bcl-B, and Bcl-w), multidomain proapoptotic (including Bax, Bak, and Bok), and proapoptotic BH3 only (Bid, Bad, Bmf, Bik, Puma, Noxa, Hrk, and BNip3). Zebrafish Bax-2 displays significantly greater sequence homology to mammalian Bax. Zebrafish Bax-2 was functionally similar to human Bak, in that it was unable to interact functionally with zebrafish Blp2, the homolog of mammalian Bcl-2. Thus, despite the lack of homology between zebrafish and human Bak, zebrafish Bax-2 has evolved to display the same interactive selectivity as hBak. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control:B0175-18N Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0175-18M
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Hughes P, et al. Curr. Dir. Autoimmun. 2006; 9: 74-94. 2. Borner C. Mol. Immunol. 2003;39:615-647. 3. Willis S N, et al. Genes Dev. 2005; 19: 1294-1305.
Additional info: Recognizes zebrafish Bax beta.

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