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BCAS2 pAb

BCAS2 pAb

Cat no: BS5626

Supplier: Bioworld Technology, Inc.
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BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligandindependent manner) with TR(beta) (thyroid hormone receptor (beta)), ER(alpha) (estrogen receptor (alpha)), ER(beta), PR (progesterone receptor), and PPAR(gamma) (Peroxisome proliferator-activated receptor (gamma)). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer.
Catalogue number: BS5626
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug/100ul
Swiss prot: O75934
Dilutions: WB: 1:500~1:1000 ICC: 1:50~1:200 IP: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 180-225 of Human BCAS2.
Species: BCAS2 pAb detects endogenous levels of BCAS2 protein.
Molecular weight: ~ 26 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Pre-mRNA-splicing factor SPF27; Breast carcinoma-amplified sequence 2; DNA amplified in mammary carcinoma 1 protein; Spliceosome-associated protein SPF 27; DAM1
Additional info: For research use only, not for use in diagnostic procedure.

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