BCL-10 (4F8) Antibody

Cat no: 252596

Supplier: ABBIOTEC

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Description
Additional Information

Bcl-10 (B-cell CLL/lymphoma 10) is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappa. Bcl-10 interacts with CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a comple, Xenopus/Amphibian, with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaBovine, and the deregulation of either of them may contribute tothe same pathogenetic process that leads to the malignancy.

Catalogue number:	252596
Reactivities:	Human, Mouse
Applications:	Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size:	0.1 mg
Accession:	O95999
Antigen:	Purified recombinant fragment of human BCL-10 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	4F8E8H8,4F8E3H8
Additional info:	Bcl-10; B-cell lymphoma/leukemia 10; B-cell CLL/lymphoma 10; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; CARD-containing molecule enhancing NF-kappa-B; Cellular homolog of vCARMEN; cCARMEN; Mammalian CARD-containing adapter molecule E10; mE10; Cellular-E10; c-E10; CARD-like apoptotic protein; hCLAP; BCL10; CIPER; CLAP