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Bcl 2, aa1-211, Recombinant, Human (B-cell lymphoma protein 2 alpha, Apoptosis regulator Bcl-2, Bcl-2)

Cat no: B0807-02F


Supplier: United States Biological
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Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apotosis. Bcl-2 exerts its anti-apoptotic function through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). The Bcl-2 gene has been related with a number of cancers, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity. Source: Recombinant Bcl-2 protein was expressed in E.coli. Molecular Weight: 25.4kD (231aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF D Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B0807-02F
Size: 50ug
Form: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, 2mM DTT, 20% glycerol.
Purity: (same/more than)90% by SDS-PAGE
References: 1. Zamzami N., et al. (1998) Oncogene. 16(17):2265-82, 2. Fernandez-Sarabia MJ., et al. (1993) Nature. 366(6452):274-5.

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