Home  >  Products  >  Bcl 2 (B Cell Leukemia 2, B Cell Leukemia/lymphoma 2, B Cell Lymphoma 2, B-cell CLL/lymphoma 2, Bcl2, Bcl-2 Protein, Apoptosis Regulator Bcl 2, Apoptosis Regulator Bcl2)
Bcl 2 (B Cell Leukemia 2, B Cell Leukemia/lymphoma 2, B Cell Lymphoma 2, B-cell CLL/lymphoma 2, Bcl2, Bcl-2 Protein, Apoptosis Regulator Bcl 2, Apoptosis Regulator Bcl2)

Bcl 2 (B Cell Leukemia 2, B Cell Leukemia/lymphoma 2, B Cell Lymphoma 2, B-cell CLL/lymphoma 2, Bcl2, Bcl-2 Protein, Apoptosis Regulator Bcl 2, Apoptosis Regulator Bcl2)

Cat no: B0807-03P

Supplier: United States Biological
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Members of the Bcl-2 family of proteins are important regulators of programmed cell death (reviewed in 1-3). This family of proteins includes both anti-apoptotic molecules such as Bcl-2 and Bcl-X(L), and pro-apoptotic molecules such as Bax, Bak, Bid, and Bad. The deregulation of the various Bcl-2 family member proteins has been implicated in many pathological conditions. For example, overexpression of anti-apoptotic molecules including Bcl-2, Bcl-X(L), or both has been associated with a number of human cancers, and may play a critical role in cancer progression. For example, constitutive expression of Bcl-2, such as in the case of translocation of Bcl-2 to Ig heavy chain locus, is thought to cause follicular lymphoma. Anti-apoptotic Bcl-2 family members appear to function, at least in part, by interacting with and antagonizing pro-apoptotic family members. The Bcl-2 gene generates two transcript variants, alpha and beta which are produced by alternate splicing and differ in their C-terminal ends. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0807-03P
Reactivities: Human, Mouse, Rat, Bovine
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Kirkin V, Joos S, and Zornig M. 2004. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta. 1644:229-249. 2. Chan SL and Yu VC. 2004. Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities. Clin Exp Pharmacol Physiol. 31:119-128. 3. Soreson CM. 2004. Bcl-2 family members and disease. Biochim Biophys Acta. 1644:169-177.
Additional info: Recognizes human Bcl-2. Species sequence homology: mouse, rat, pufferfish, bovine.

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