Bcl-2, NT (Apoptosis Regulator Bcl-2, BCL2)

Cat no: B0807-05V

Supplier: United States Biological

0 reviews | Write a Review Pencil

Read More on Supplier Website

Description
Additional Information

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis. It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad. Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer. Overexpression of zebrafish Bcl2 resulted in a quick onset of leukemia in zebrafish model. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: B0807-05W Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	B0807-05V
Reactivities:	Zebrafish/Fish
Hosts:	Rabbit
Applications:	ELISA, Western Blot
Size:	250ul
Form:	Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
References:	1. Edwards, SW. et al. Biochem Soc Trans. 32, 489 (2004). 2. Cuconati, A. et al. Genes and Dev. 17, 2922 (2003). 3. Opferman, JT. et al. Nature 426, 671 (2003). 4. Kozopas, KM. et al. Proc. Natl. Acad. Sci. USA 90, 3516 (1993). 5. Rinkenberger, JL. et al. Genes and Dev. 14, 23 (2000). 6. Bae, J. et al. J. Biol. Chem. 275, 25255 (2000). 7. Chen J. et al. Leukemia 21(3): 462-71 (2007).
Additional info:	Recognizes zebrafish Bcl2.

See Full Product Listings >

Bcl-2, NT (Apoptosis Regulator Bcl-2, BCL2)

Cat no: B0807-05V

Get Quote

About Biosave

Product Categories

Information


Get a Quote Direct from United States Biological




By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*