Home  >  Products  >  Bcl 3 (B Cell CLL/lymphoma 3, B Cell Leukemia 3, B Cell Leukemia/lymphoma 3, B Cell Lymphoma 3 Encoded Protein, BCL3, BCL4, Chronic Lymphatic Leukemia Protein, D19S37, Protein Bcl 3)
Bcl 3 (B Cell CLL/lymphoma 3, B Cell Leukemia 3, B Cell Leukemia/lymphoma 3, B Cell Lymphoma 3 Encoded Protein, BCL3, BCL4, Chronic Lymphatic Leukemia Protein, D19S37, Protein Bcl 3)

Bcl 3 (B Cell CLL/lymphoma 3, B Cell Leukemia 3, B Cell Leukemia/lymphoma 3, B Cell Lymphoma 3 Encoded Protein, BCL3, BCL4, Chronic Lymphatic Leukemia Protein, D19S37, Protein Bcl 3)

Cat no: B0807-10G

Supplier: United States Biological
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The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the I-kappa-B subfamily of inhibitors of NF-kappa-B transcription factors. Bcl-3 does not have DNA-binding activity, but it interacts with NF-kappa-B1 and NF-kappa-B2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NF-kappa-B family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney and testes. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml Optimal dilutions to be determined by the researcher. Positive control: Jurkat T cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B0807-10G
Reactivities: Human, Mouse
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4. No preservative added.
P type: Mab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Mitchell T.C., et al., (2001), Nature Immunology, 2:397-402. 2. Watanabe, N., et al., (1997), EMBO J., 16: 3609-3620. 3. Nolan, G.P., et al., (1993), Molecular and Cellular Biology, 13: 3557-3566.
Additional info: Recognizes mouse Bcl-3 at ~46-52kD. Species Crossreactivity: human.

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