BCL-XL

Cat no: B0807-16C

Supplier: United States Biological

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Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal ofDmaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: A549 cell lysates. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	B0807-16C
Reactivities:	Human
Hosts:	Rabbit
Applications:	Western Blot
Size:	50ug
Form:	Supplied as a liquid in PBS, 0.02% sodium azide.
P type:	Pab
Isotype:	IgG
Purity:	Purified
References:	1. Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7. 2. Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607. 3. Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35. 4. Gonzalez-Garcia M, Perez-Ballestro R, Ding L et al. bcl-xL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 1994; 120:3033-42. 5. Zapata JM, Krajewska M, Krajewski S, et al. Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors. Breast Cancer Res. Treat 1998; 47:129-40. 6. Zhan Q, Alamo I, Yu K, et al. The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p53 function. Oncogene 1996; 13:2287-93. 7. Tu Y, Renner S, Xu F, et al. BCL-X expression in multiple myeloma: possible indicator of chemoresistance. Cancer Res. 1998; 58:256-62.
Additional info:	Recognizes human Bcl-XL.

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BCL-XL

Cat no: B0807-16C

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