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Bcl-XL, ID

Bcl-XL, ID

Cat no: B0807-17A

Supplier: United States Biological
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Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: B0807-17P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0807-17A
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lockshin, RA. et al. Cell Death Differ. 7, 2 (2000). 2. Cory, S. et al. Oncogene 22, 8590 (2003). 3. Heiser, D. et al. Exp. Geron. 39, 1125 (2004). 4. Gonzalez-Garcia, M. et al. Development 120, 3033 (1994). 5. Zapata, JM. et al. Breast Cancer Res. Treat 47, 129 (1998). 6. Zhan, Q. et al. Oncogene 13, 2287 (1996). 7. Tu, Y. et al. Cancer Res. 58, 256 (1998).
Additional info: Recognizes zebrafish Bcl-2L.

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