Bcl-XL (28kD) is part of the Bcl-2 family, which are important regulators of apoptosis. Bcl-X has two isoforms, Bcl-XL (long) a 241aa protein and shares signi?cant homology with Bcl-2; Bcl-XS (short) a 178aa protein lacking a 63aa domain near the transmembrane region that is well conserved among members of the Bcl-2 family. Like Bcl-2, Bcl-XL has the ability to inhibit apoptosis and is widely studied for its role in tumor generation. In a recent study, analysis of Hodgkin's disease showed that 71% of cases (114/160) showed immunohistochemical reactivity with Bcl-XL in Reed-Sternberg cells. In some cases, Bcl-XL reactivity was present in Reed-Sternberg cells that were negative for CD15 and CD30. Atypical hyperplasias (0/28) were negative for Bcl-XL.
Bcl-XL prevents apoptosis through two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outermembrane of mitochondria to help maintain a normal membrane state under stress conditions.
Source:
Recombinant human Bcl-xL, aa1-212, with C-terminal HIS tag, expressed in E. coli.
Molecular Weight: 28kD
Applications:
Suitable for use in the study of apoptosis, screening inhibitors, and selectivity profiling. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
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