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BCL3 (B-cell Lymphoma 3 Protein, BCL-3, Proto-oncogene BCL3, BCL4, D19S37)

BCL3 (B-cell Lymphoma 3 Protein, BCL-3, Proto-oncogene BCL3, BCL4, D19S37)

Cat no: B0807-10H

Supplier: United States Biological
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NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. The proto-oncoprotein Bcl-3 is a member of the IkB family and is present predominantly in the nucleus. IkBa and Bcl-3 are similar in the central ankyrin repeat domains, where as they differ at the N- and -C-terminus. These differences may explain the differential binding of IkBa and Bcl-3. Two molecules of Bcl-3 can associate with NF-kB, where as only one molecule of IkBa bind to NF-kB. BCL-3 mRNA and protein expression are induced by NF-kB-activating agents. Down-regulation of BCL-3 induction results in prolonged, enhanced NF-kB binding and increased NF-kB-dependent transcription. Several cytokines, such as, TNFa or IL-1b, and mitogens as phorbolester (PMA) trigger rapid formation of Bcl-3-p50 complexes with the same kinetics as activation of p50-p65 complexes. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0807-10H
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Verma, I.M., Stevenson, J.K., Schwarz, E.M., Van Antwerp, D. & Miyamoto, S. Genes. Dev. 9: 2723-2735, (1995). 2. Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Muller CW. EMBO J 20(22): 6180-6190 (2001). 3. Brasier AR, Lu M, Hai T, Lu Y, Boldogh I. J Biol Chem 276(34): 32080-32093 (2001). 4. Hunter RB, Stevenson E, Koncarevic A, Mitchell-Felton H, Essig DA, Kandarian SC. FASEB J 16(6): 529-538 (2002).
Additional info: Recognizes human Bcl-3. Species sequence homology: mouse and rat.

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