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BCMA, CT (Tumor Necrosis Factor Receptor Superfamily Member 17, B-cell Maturation Protein, CD269, TNFRSF17, BCM)

BCMA, CT (Tumor Necrosis Factor Receptor Superfamily Member 17, B-cell Maturation Protein, CD269, TNFRSF17, BCM)

Cat no: B0807-50F

Supplier: United States Biological
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Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL- 2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-5ug/ml Immunohistochemistry: 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human spleen tissue, K562, or U937 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B0807-50F
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Moore PA, et al (199) Science. 285:260-3. 2. Schneider P, et al (1999) J. Exp. Med. 189:1747-56. 3. Shu HB, et al (1999) J. Leukoc. Biol. 65:680-3. 4. Mukhopadhyay A, et al (1999) J. Biol. Chem. 274:15978-81. 5. Hahne M, et al (1998) J. Exp. Med. 188:1185-90. 6. Gross JA, et al (2000) Nature. 404:995-9. 7. Thompson JS, et al (2001) Science. 293:2108-11. 8. Laabi Y, et al (1994) Nucleic Acids Res. 22:1147-54.
Additional info: Recognizes human BCMA.

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