BCR (Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26BCR1, D22S11)

Cat no: B0094-29

Supplier: United States Biological

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The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot:1:500-1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	B0094-29
Reactivities:	Human, Mouse
Hosts:	Rabbit
Applications:	Western Blot
Size:	50ug
Form:	Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
Additional info:	Recognizes human BCR. Species Cross-Reactivity: mouse.

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BCR (Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26BCR1, D22S11)

Cat no: B0094-29

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