Home  >  Products  >  Bcr, phosphorylated (Tyr177) (Breakpoint Cluster Region, BCR 1, BCR1, BCR-ABL1, Bcr-abl1 e14a3 Chimeric Protein, BCR/ABL e14a2 Fusion Protein, CML, PHL, Renal Carcinoma Antigen NY-REN-26)
Bcr, phosphorylated (Tyr177) (Breakpoint Cluster Region, BCR 1, BCR1, BCR-ABL1, Bcr-abl1 e14a3 Chimeric Protein, BCR/ABL e14a2 Fusion Protein, CML, PHL, Renal Carcinoma Antigen NY-REN-26)

Bcr, phosphorylated (Tyr177) (Breakpoint Cluster Region, BCR 1, BCR1, BCR-ABL1, Bcr-abl1 e14a3 Chimeric Protein, BCR/ABL e14a2 Fusion Protein, CML, PHL, Renal Carcinoma Antigen NY-REN-26)

Cat no: B0808-31A

Supplier: United States Biological
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The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160kD protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: B0808-31A
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Clark, S. S., McLaughlin, J., Timmons, M., Pendergast, A. M., Ben-Neriah, Y., Dow, L. W., Crist, W., Rovera, G., Smith, S. D. and Witte, O. N. (1988). Science 239, 775-777 2. Konopka, J. B., Watanabe, S. M. and Witte, O. N. (1984). Cell 37, 1035-1042 3. Boguski, M. S. and McCormick, F. (1993). Nature 366, 643-654. 4. Braselmann, S. and McCormick, F. (1995). EMBO J. 14, 4839-4848
Additional info: Recognizes human Bcr when phosphorylated at Tyr177.

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