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BD3 (beta Defensin-3, CTIP1)

BD3 (beta Defensin-3, CTIP1)

Cat no: B0902-02A

Supplier: United States Biological
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A novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and clones from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomyosin-resistant Entoerococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3, therefore, might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 (ECL) Immunohistochemistry: frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B0902-02A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified IgG
References: 1. Harder, J., Bartels, J., Christophers, E. and Schroder, JM, J. Biol Chem. Feb 23; 276(8): 5707-5713 (2001). 2. Supp, DM., et al. Expression of Human Beta-Defensins HBD-1, HBD-2, and HBD-3 in Cultured Keratinocytes and Skin Substitutes. National Library of Medicine. 7:643-8, 2004. 3. Kozar, R.A., Santora, R.J., Poindexter, B.J., et al. Alterations in content and localization of defensins in rat ileum and jejunum following ischemia-reperfusion. Specific peptides, in specific places, for specific jobs? Eplasty. (2011);11:e8. 4. Akiyama, M., Sakai, K., Takayama, C., et al. CGI-58 Is an {alpha}/{beta}-Hydrolase within Lipid Transporting Lamellar Granules of Differentiated Keratinocytes. Am J Pathol (2008)173:1349-1360.
Additional info: Recognizes human hBD-3. Species Sequence Homology: canine and porcine

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