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Beclin-1, CT (Coiled-coil Myosin-like Bcl-2-Interacting Protein)

Beclin-1, CT (Coiled-coil Myosin-like Bcl-2-Interacting Protein)

Cat no: B0981-23J

Supplier: United States Biological
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May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in autophagy. SUBUNIT: Interacts with GOPC and GRID2. Interacts with Bcl-2. Cellular Localization: Cytoplasm (Potential). Golgi apparatus; Golgi membrane; peripheral membrane protein. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. Tissue Specificity: Ubiquitous. Belongs to the beclin family. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B0981-23J
Reactivities: Human
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
P type: Pab
Purity: Serum
Alternative names: ATG6, BECN1, GT197, VPS30
References: 1. Liang,X.H., et al. J. Virol. 72 (11), 8586-8596 (1998) ; 2. Aita V.M., et al. Genomics 59:59-65(1999). ; 3. Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004) ; 4. Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) ; 5. Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) ; 6. Levine B. Cell. 120(2):159-62. (2005)
Additional info: IHC and WB confirmed the specificity for Beclin-1. Species Crossreactivity: Human

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