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SPECIFICATIONS
Price
323.00 USD
Catalog Number
CAC07912
Size
100 micro g
Applications
IF, IHC, WB
Hosts
Rabbit
Conjugates
Unconj
Purity
Protein G purified, >95%
Target
BECN1
Clonality
Polyclonal
Storage Temp
Aliquot and store at -20 degrees C. Minimize freezing and thawing.
Research Area
For research use only. Not for diagnostic procedures.
Shipping Temp
Blue ice
Additional Info
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Alternative Names
Beclin-1,Coiled-coil myosin-like BCL2-interacting protein,Protein GT197,Beclin-1-C 35 kDa,BECN1,GT197
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