Supplier:
Alomone Labs Ltd.Cat no: B-120
Benidipine hydrochloride\n
Ca2+ channel blockers (CCBs) are a diverse class of pharmaceutical agents, usually targeted at CaV1s, of which dihydropyridines (DHPs) constitute a major subgroup. Inhibitors of Ca2+-mediated smooth muscle contractions, CCBs produce vasodilation, thus therapeutically managing hypertension and coronary heart disease. Additionally, benidipine is known to be an endothelium protectant as well as an antioxidant.
A DHP derivative, benidipine hydrochloride acts as a triple-channel (CaV1, CaV2 and CaV3) blocker and is characterized by slow onset of action and high affinity for the binding sites of its target channels; with a Ki value of 0.08-0.13 nmol/L benidipine's cell-membrane association is considerably greater than other DHPs, and a dissociation rate which is 9 times slower than that of nifedipine makes it distinguishably long-lasting.
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SPECIFICATIONS
Catalog Number
B-120
Size
10 mg
Purity
>99%
Concentration
1-100 uM
Shipping Temp
Room Temperature
Molecular Weight
542.0 Da
SUPPLIER INFO
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