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Benzo[a]pyrene-Diol Epoxide (BPDE)

Benzo[a]pyrene-Diol Epoxide (BPDE)

Cat no: B1074A

Supplier: United States Biological
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Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) from occupational, environmental, and medical sources. Benzo[a]pyrene is a carcinogenic PAH found in cigarette smoke, heavily polluted air and smoked foods. A diol epoxide derivative of benzo[a]pyrene, 7b, 8a-dihydroxyn -9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I) has been implicated as the key mutagenic benzo[a]pyrene metabolite involved in covalent modification of DNA. Applications: Suitable for use in ELISA and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B1074A
Hosts: Mouse
Applications: ELISA, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, 50% glycerol.
P type: Mab
Isotype: IgG1,k
Purity: Purified
References: 1. Santella, R.M. et al. (1984) Carcinogenesis 5:373. 2. Lee, B.M. and R.M. Santella (1988) Carcinogenesis 9:1773. 3. Strickland, P.T., et al.,1994. Carcinogenesis 15:483-487.4. Kang, D.H., et al., 1995. Carcinogenesis 16:1079-1085.5 . Kang , D.H., et al., 1995. Occupational and Environmental Medicine 52:593-599.
Additional info: Recognizes both free polycyclic aromatic hydrocarbons (PAHs) and DNA adducts. In an inhibition assay, the binding of B1074A to BPDE adducts was inhibited by BPDE-1-DNA, BPDE-1-dG, BPDE-1 tetraol, but not by BPDE-II-DNA.

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