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Berninamycin A (Berninamycin, Antibiotic U27810)

Berninamycin A (Berninamycin, Antibiotic U27810)

Cat no: B1078-75

Supplier: United States Biological
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Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistence. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1. DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water
Catalogue number: B1078-75
Size: 1mg
Form: White solid
Purity: >99%
Alternative names: Berninamycin, Antibiotic U27810
References: 1. Berninamycin. I. The structure of berninamycinic acid. Liesch, J.M. et al., J.Am.Chem.Soc. 1976, 98, 299. 2. Mode of action of berninamycin. An inhibitor of protein biosynthesis. Reusser F. Biochem. 1969, 8, 3303. 3. Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et. al. , Cancer Res. 2006, 19, 9731.

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