Beta-Amyloid [1-16] Antibody

Cat no: 250921

Supplier: ABBIOTEC

0 reviews | Write a Review Pencil

Description
Additional Information

Beta-amyloid production results from cleavage in the e, Xenopus/Amphibian,tracellular domain of APP by the beta-secretase (BACE1) , which results in the production of the APP C-terminal fragment C99. This fragment is further cleaved by the gamma-secretase at residues 40-42 to produce beta-amyloid 40 and 42 peptides. Beta-amyloid aggregation and neuritic plaque formation are pathologic hallmarks of Alzheimer disease. The (1-16) fragment is the amino terminus of beta-amyloid. The binding of this antibody to amyloid beta-peptide depends on the presence of residues 10-16.

Catalogue number:	250921
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P05067
Antigen:	KLH-conjugated synthetic peptide encompassing the sequence (1-16) of human Beta Amyloid.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Polyclonal Antibody
Isotype:	Mouse Ig
Additional info:	APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease ne, Xenopus/Amphibian,in-II; PN-II; APPI; PreA4