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Beta-arrestin 1/2 Antibody

Beta-arrestin 1/2 Antibody

Cat no: 251344

Supplier: ABBIOTEC
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Beta-arrestins function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein. Beta-arrestin binding appears to require additional receptor determinants e, Xenopus/Amphibian,posed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adaptor protein 2 comple, Xenopus/Amphibian, 2 (AP-2) in clathrin-coated pits (CCPs). This antibody recognizes beta-arrestin-1 and beta-arrestin-2. The e, Xenopus/Amphibian,tent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type.
Catalogue number: 251344
Reactivities: Human, Mouse, Bovine, Chicken/Bird, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P49407; P32121
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human beta-arrestin 1/2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: beta-arrestin 1; beta-arrestin 2; beta-arrestin 1/2; Beta-arrestin-1/2; Beta-arrestin-1; Arrestin beta-1; ARRB1; Beta-arrestin-2; Arrestin beta-2; ARRB2
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