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Bid, ID (BH3-interacting Domain Death Agonist, p22 BID)

Bid, ID (BH3-interacting Domain Death Agonist, p22 BID)

Cat no: B1095-05E

Supplier: United States Biological
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Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl- 2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bid, a member of pro-apoptotic Bcl-2 family, is cleaved by caspase-8 in response to apoptotic signals, exposing the Bcl-2 homology 3 (BH3) domain, which is normally buried in the full-length protein. The cleaved complex is myris-toylated and translocated to the mitochondrial membrane, where it may induce mitochondrial Bax and Bak to oligomerize. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B1095-05E
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Ion Exchange chromatography.
References: 1. Lockshin, RA. et al. Cell Death Differ. 7, 2 (2000). 2. Cory, S. et al. Oncogene 22, 8590 (2003). 3. Heiser, D. et al. Exp. Geron. 39, 1125 (2004). 4. Wang, K. et al. Genes Dev. 10, 2859 (1996). 5. Li, H. et al. Cell 94, 491 (1998). 6. Chou, JJ. et al. Cell 96, 615 (1999). 7. Zha, J. et al. Science 290, 1761 (2000). 8. Wei, MC. et al. Genes Dev. 14, 2060 (2000).
Additional info: Recognizes human Bid. Species Crossreactivity: mouse.

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