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Bif (Endophilin-B1, Bax-interacting Factor 1, Bif-1, SH3 Domain-containing GRB2-like Protein B1, SH3GLB1, KIAA0491, CGI-61)

Bif (Endophilin-B1, Bax-interacting Factor 1, Bif-1, SH3 Domain-containing GRB2-like Protein B1, SH3GLB1, KIAA0491, CGI-61)

Cat no: B1098-01J

Supplier: United States Biological
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Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family such as Bax appear to control the activation of these enzymes. Bax activity was found to be regulated by its association with Bax- interacting factor 1 (Bif), a member of the endophilin B family that is associated with intracellular membranes. Following this interaction, Bax undergoes a conformational change and translocates to mitochondrial membranes. The Bax/Bif interaction appears to be enhanced by apoptotic stimuli, suggesting that Bif acts as the trigger to activate Bax, and as suppression of Bif promoted HeLa cell colony formation in soft agar, it may have a role in the suppression of cancer progression. At least two isoforms of BIF are known to exist. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HeLa cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B1098-01J
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lockshin, RA. et al.Cell Death Differ. 7, 2 (2000). 2. Oltvai, ZN, et al. Cell 74, 609 (1993). 3. Cuddeback, SM. et al. J. Biol. Chem. 276, 20559 (2001). 4. T akahashi, Y . et al. Mol. Cell. Biol. 25, 9369 (2005).
Additional info: Recognizes human Bif. Species Crossreactivity: mouse.

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