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BIK (Bcl 2 Interacting Killer, BCL-2-interacting Killer, Apoptosis Inducer NBK, BIP1, BP4, NBK)

BIK (Bcl 2 Interacting Killer, BCL-2-interacting Killer, Apoptosis Inducer NBK, BIP1, BP4, NBK)

Cat no: B1098-88

Supplier: United States Biological
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Loss of Bik is a common feature of clear-cell renal cell carcinoma (RCC), and is thought to act as a renal tissue-specific tumor suppressor gene. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B1098-88
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Mathai, J.P. et al. (2005) BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. J. Biol. Chem. 280: 23829-23836. 2. Real, P.J. et al. (2006) Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells. FEBS Lett. 580: 5905-5909. 3. Sturm, I. et al. (2006) Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma. Cell Death Differ. 13: 619-627.
Additional info: Recognizes human BIK (N-TERMINAL). Species Crossreactivity: mouse.

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