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Bim (Bcl-2-like Protein 11, Bcl2-L-11, Bcl2-interacting Mediator of Cell Death, BCL2L11)

Bim (Bcl-2-like Protein 11, Bcl2-L-11, Bcl2-interacting Mediator of Cell Death, BCL2L11)

Cat no: B1090-03F

Supplier: United States Biological
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Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: K562 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B1090-03F
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. O'Connor, L. et al. EMBO J. 17, 384 (1998). 2. Hsu, SY. et al.. Mol. Endocrinol. 12, 1432 (1998).
Additional info: Recognizes human Bim. Species Crossreactivity: mouse and rat.

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