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Biotin anti-human C3a/C3a(desArg)/C3

Biotin anti-human C3a/C3a(desArg)/C3

Cat no: 518002

Supplier: BioLegend
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C3, complement component 3, is a 195 KD glycoprotein heterodimer that is linked by disulfide bonds. It is the fourth complement component to react in the classical pathway and it is also a reactant in the alternative complement pathway. C3 convertase splits C3 into C3b and C3a. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Macrophages and neutrophils have receptors for C3b. C3a is released into the surrounding fluids. It can bind to receptors on basophils and mast cells triggering them to release their vasoactive contents (e.g., histamine). Because of the role of these materials in anaphylaxis, C3a is called an anaphylatoxin. In blood, the C3a fragment is rapidly desarginated by serum carboxypeptidase N enzyme to generate C3a desArg. Both C3a and C3a desArg are not glycosylated.
Catalogue number: 518002
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Conjugates: Biotin
Size: 500 microg
Clone: D17/1
Gene: 718
Dilutions: Each lot of this antibody is quality control tested by ELISA assay. For ELISA detection applications, a concentration range of 0.5-2 microg/ml is recommended. To obtain a linear standard curve, serial dilutions of C3a recombinant protein ranging from39 to 2500 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: Human C3a
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: C3a, C3a desarg, C3, complement component 3, complement C3 alpha chain
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