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Biotin anti-human CD215 (IL-15Ralpha)

Biotin anti-human CD215 (IL-15Ralpha)

Cat no: 330204

Supplier: BioLegend
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IL-15 receptor alpha (IL-15Ralpha) is a cytokine receptor with the structural homology to IL-2Ralpha (CD25). Both alpha receptors contain a group of beta sandwich protein called sushi domains. Similar to IL-2Ralpha, IL-15Ralpha is able to form a heterotrimer with their beta chain (CD122) and common gamma chain (gammac, CD132). But unlike IL-2Ralpha subunit, IL-15Ralpha itself binds to IL-15 with equivalent high affinity compared with the heterotrimeric complex. IL-15Ralpha is expressed as soluble or transmembrane forms by variety cells, such as activated monocytes, dendritic cells, CD8+ memory T cells, NK or NKT cells. IL-15Ralpha by itself forms stable complexes with IL-15 on cell surface and presents IL-15 in trans to neighboring cells. IL-15, like IL-2, is a pleiotropic four-helix bundle cytokine and plays a key role in promoting T and B cell survival and proliferation, preferentially in memory CD8+ T cell proliferation, and NK/NKT cell development.
Catalogue number: 330204
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Conjugates: Biotin
Size: 100 microg
Clone: JM7A4
Gene: 3601
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration: 0.5 mg/ml
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: IL-15R a chain
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