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Biotin anti-human IL-23 (p19)

Biotin anti-human IL-23 (p19)

Cat no: 511204

Supplier: BioLegend
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The HLT2736 clone recognizes human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a capture antibody in ELISA. IL-23 is secreted by activated dendritic cells and macrophages and has been shown to enhance IFN-gamma secretion by memory (CD45RO) T cells in an IL-2 dependent manner. IL-23 may also induce unique Th subset (designated ThIL-17) that secretes the cytokines IL-17, IL-6, TNF and low levels of IFN-gamma. IL-23 has been shown to promote immunity to mycobacteria and has been shown to be upregulated in response to some viral infections and in psoriatic lesions. IL-23 binds to the IL-23 receptor comprised of a beta1 subunit shared with the IL-12 receptor and IL-23-specific subunit. This antibody has been shown to be useful for Western blotting, immunohistochemistry using formalin-fixed, paraffin embedded tissues with (catalyzed signal amplification), and immunoprecipitation.
Catalogue number: 511204
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Conjugates: Biotin
Size: 500 microg
Clone: HLT2736
Gene: 51561
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting applications, a concentration range of 0.5 microg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: Human recombinant p40 and p19 with elastin linker
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Interleukin-23 p19,
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