Biotin anti-mouse CD244.2 (2B4 B6 Alloantigen)

Mouse CD244, also known as 2B4, is a receptor belonging to the CD2 family of proteins involved in non- MHC-restricted cytotoxicity. It is expressed on all natural killer (NK) cells, IL-2 activated NK (LAK) cells, NKT cells, and a subset of T lymphocytes, including dendritic epidermal T cells. At least there are two isoforms of CD244.2 proteins that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner, while the short form functions in an activating manner. The ligand of CD244 is CD48, which expressed on all hematopoietic cells. It was reported that CD244 interacts with CD48 is essential for IL-2-driven expansion and activation of murine NK cells. The 2B4 antibody reacts with CD244.2, the 2B4 allloantigen which is expressed on C57BL/6 mice, but not on Balb/c mice.

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SPECIFICATIONS

Catalog Number

133506

Size

200 microg

Applications

FC

Hosts

Mouse

Reactivities

Mouse

Conjugates

Biotin

Clone

m2B4 (B6)458.1

Antigen

m2B4-Fc

Gene Id

78369

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

2B4 B6 Alloantigen

Regulatory Status

RUO