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Biotin anti-mouse CD278 (ICOS)

Biotin anti-mouse CD278 (ICOS)

Cat no: 117403

Supplier: BioLegend
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The 7E.17G9 antibody reacts with the 47-57 kD ICOS protein, also known as inducible costimulatory molecule, and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.
Catalogue number: 117403
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Conjugates: Biotin
Size: 50 microg
Clone: 7E.17G9
Gene: 100048841
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is = 0.25 microg per 106 cells in 100 microl volume.
Storage buffer: The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Isotype: Rat IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Inducible COStimulatory molecule, H4
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