Biotin anti-mouse CD279 (PD-1)

Cat no: 135212

Supplier: BioLegend

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Description
Additional Information

CD279, known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein and belongs to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T, B lymphocytes, and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It was reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Catalogue number:	135212
Reactivities:	Mouse
Hosts:	Rat
Applications:	Flow Cytometry
Conjugates:	Biotin
Size:	500 microg
Clone:	29F.1A12
Gene:	18566
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration:	0.5 mg/ml
Antigen:	PD-1 cDNA followed by PD-1-Ig fusion protein
Isotype:	Rat IgG2a, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Programmed Death-1, PD1