Biotin anti-mouse CD357 (GITR)

Cat no: 126306

Supplier: BioLegend

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Description
Additional Information

GITR glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18,and AITR (in humans).It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Treg cells.The expression of GITR on T cells can be upregulated upon activation.Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-kB activation, and abrogate the inhibitory function ofCD25+CD4+ T reg cells.In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Catalogue number:	126306
Reactivities:	Mouse
Hosts:	Rat
Applications:	Flow Cytometry
Conjugates:	Biotin
Size:	200 microg
Clone:	DTA-1
Gene:	21936
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration:	0.5 mg/ml
Antigen:	mouse CD25+CD4+ T cells
Isotype:	Rat IgG2b, lambda
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	AITR, TNFRSF18