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Biotin anti-mouse CD49d

Biotin anti-mouse CD49d

Cat no: 103603

Supplier: BioLegend
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CD49d is a 150 kD glycoprotein, also known as alpha4 integrin or VLA-4 alpha chain. It is a member of the integrin family, expressed on T and B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. CD49d is a heterodimer expressed with either of two beta chains, beta1 (CD29) or beta7, to form the VLA-4 (integrin alpha4beta1) or LPAM-1 (integrin alpha4beta7) complexes. CD49d plays a critical role in both adhesion and T cell costimulation. The primary ligands for CD49d are VCAM-1, MAdCAM-1, and fibronectin. The R1-2 antibody has been shown to partially block CD49d mediated interactions and, in combination with the 9C10(MFR4.B) antibody, completely blocks VCAM-1 binding to VLA-4.
Catalogue number: 103603
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Conjugates: Biotin
Size: 50 microg
Clone: R1-2
Gene: 16401
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: AKR/Cum mouse spontaneous T lymphoma line TK1
Isotype: Rat IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: alpha4 integrin, VLA-4 alpha chain, integrin a4
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