Biotin anti-mouse TNF-alpha

Cat no: 506312

Supplier: BioLegend

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TNF-alpha is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF-alpha. Monomeric mouse TNF-alpha is a 156 amino acid protein (N-glycosylated) with a reported molecular weight of 17.5 kD. TNF-alpha forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-alpha has also been described. TNF-alpha binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorrhagic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

Catalogue number:	506312
Reactivities:	Mouse
Hosts:	Rat
Applications:	Flow Cytometry, Immunocytochemistry
Conjugates:	Biotin
Size:	500 microg
Clone:	MP6-XT22
Gene:	21926
Dilutions:	Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA detection antibody, a concentration range of 0.25-1.0 microg/ml is recommended. To obtain a linear standard curve, serial dilutions of mouse TNF-alpha recombinant protein ranging from 500 to 4 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration:	0.5 mg/ml
Antigen:	E. coli-expressed, recombinant mouse TNF-alpha
Isotype:	Rat IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Tumor necrosis factor-alpha, Cachectin, Necrosin, Macrophage cytotoxic factor (MCF), Differentiation inducing factor (DIF), TNFSF2

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Biotin anti-mouse TNF-alpha

Cat no: 506312

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