Home  >  Products  >  BIRC1, CT (Baculoviral IAP Repeat-containing Protein 1, Neuronal Apoptosis Inhibitory Protein, NAIP)
BIRC1, CT (Baculoviral IAP Repeat-containing Protein 1, Neuronal Apoptosis Inhibitory Protein, NAIP)

BIRC1, CT (Baculoviral IAP Repeat-containing Protein 1, Neuronal Apoptosis Inhibitory Protein, NAIP)

Cat no: B2049-80C

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neuro-degenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70aa motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules. Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: PC-3 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2049-80C
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Roy N. et al. Cell 80, 167 (1995). 2. Liston P. et al. Oncogene 22, 8568 (2003). 3. Verhagen AM. et al. Genome Biol. 2, reviews3009.1 (2001). 4. Davoodi J. et al. J. Biol. Chem. 279, 40622 (2004). 5. Yamamoto K. et al. Biochem. Biophys. Res. Commun. 264, 998 (1999).
Additional info: Recognizes human NAIP.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave