Neuronal Apoptosis Inhibitory Protein (NAIP) also known as BIRC1, is a 1406aa intracellular protein belonging to the IAP family. NAIP functions in the prevention of neuron apoptosis induced by various signals. It was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. NAIP, unlike other IAPs, requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, this suggests that NAIP is unique among the IAPs in its regulation of activity. NAIP is expressed in motor, but not sensory neurons, it is also found in the liver, placenta, and to a lesser extent, spinal cord.
Applications:
Suitable for use in Immunohistochemistry (paraffin) and Western Blot. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 5ug/ml
Western Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Human placenta
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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