BIRC5 Antibody

Cat no: 250560

Supplier: ABBIOTEC

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Description
Additional Information

BIRC5 (Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor suvivin) is a component of the chromosomal passenger comple, Xenopus/Amphibian, (CPC), a key regulator of mitosis that functions at the centromere to ensure correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. With RAN, survivin forms a scaffold for mitotic spindle formation to deliver the RAN effector TP, Xenopus/Amphibian,2 to microtubules. Survivin plsys a role in neoplasia. It inhibits caspase-3 and caspase-7, blocking a default induction of apoptosis in G2/M phase. It is e, Xenopus/Amphibian,pressed in fetal kidney, liver, lung, brain, adenocarcinomas, lymphomas, renal cell carcinoma cell lines.

Catalogue number:	250560
Reactivities:	Human, Bovine, Canine, Porcine
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	O15392
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BIRC5.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit IgG
Additional info:	BIRC5; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor suvivin; Apoptosis inhibitor 4; Survivin variant; AP14; IAP4